Don (Robert Carlyle of The Full Monty), a survivor of the original zombie attack, is consumed with guilt because he had to leave his wife Alice (Catherine McCormack) behind. Six months later, the mainland of Great Britain has been quarantined and Don joins the London reconstruction effort. He is reunited with his two kids –(17-year-old Imogen Poots and 12-year-old Mackintosh Muggleton), who were out of the country when the virus first spread.

Don, who believes his wife died in the zombie attacks, soon discovers that Alice is very much alive – but, sadly, infected with the "rage virus," even though she isn't among the walking dead.

But, the virus breaks out again - you knew it was going to happen. The military is back on their kill-them-all policy, forcing citizens to flee from both the infected and the soldiers. Don oversees the infrastructure of a fortified "green zone" established for preliminary resettlement.